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diagnosis liver algorithm injury interpretation transaminitis chemistry disease drug elevation fattyliver function functiontest gastroenterology hepatitis idiosyncratic induced laboratory nafld nonalcoholic
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Chronic - ongoing ↑ LFTs ... Calculate R-Value ... • Hepatocellular ... Idiosyncratic #differential ... gastroenterology #hepatology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Function Test (LFTs ... abnormality vs bone Bili ... ) vs Indirect (Hemolytic ... ALP ≥ 2x ULN R Value ... Transaminitis #diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... • Iatrogenic: DILI ... Bilirubin: RBC (hemolysis ... injury #hepatitis #differential ... diagnosis #algorithm #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Function Tests (LFTs ... ) - Normal Values ... intrahepatic cholestasis, hepatocellular ... Overproduction (hemolysis ... Interpretation #diagnosis #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum ... chemistry #diagnosis #differential ... #Hepatology #transaminitis ... #LFTs #RValue #
Non-alcoholic fatty liver disease algorithm. For those patients with NAFLD or liver disease of unknown aetiology,
fibrosis score with values ... 4, fibrosis-4; HCC ... , hepatocellular ... algorithm #Referral #Management ... #Hepatology
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