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Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Anemia (AIHA) - ... Table Warm AIHA ... Cold Agglutinin Disease ... DAT-negative AIHA ... Hemolytic #Anemia #AIHA
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Membrane): - Autoimmune ... : Warm AIHA, Cold ... AIHA, Transfusion ... Drug-associated, PCH
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Immune-Mediated • Warm AIHA ... • Cold AIHA ... • Drug-induced AIHA ... Complement-Mediated • Cold AIHA ... Prosthetic heart valves
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Function Tests - Differential ... Viral, Ischemia, AIH ... - Viral, AIH ... Alcohol, Viral, HH, AIH ... Burak @kwburak #LFTs
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Anemia (AIHA) Treatment ... Warm AIHA: 1) Steroids ... esp if severe disease ... BrighamMedRes #AIHA ... #Anemia #AIHA #
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Ischemia • Autoimmune ... • Drugs • AIH ... • Cholestatic disease ... • Others #LFTs ... #Hepatology #LiverEnzymes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
(AIHA) "Warm" ( ... idiopathic) - Autoimmune ... (AIHA)"Cold" (usually ... Extravascular #Causes #differential ... #diagnosis #hematology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
from subclinical disease ... been reported (eg AIH-PBC ... If suspected, AIH ... #Hepatitis #AIH ... #Hepatology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Chain deposition disease ... Atypical HUS, autoimmune ... atheroembolic, AIHA ... Mnemonic #diagnosis #differential ... #hematology
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis of Autoimmune ... >1.5, and both values ... SMA >1:80 #Autoimmune ... Hepatitis #Diagnosis #Hepatology ... #AIH