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algorithm causes hematology cholangitis injury mass transaminitis workup abnormal alkaline alp biliary chemistry cholestatic cirrhosis dehydrogenase dili disorders drug elevated
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... • R value = (ALT ... #Enzymes #LFTs ... #differential # ... hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... Diagnosis Algorithm ... ALP: - Enzymes ... - Drugs - Primary ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential ... • Cholestatic disease ... • Others #LFTs ... #Hepatology #LiverEnzymes
Liver Mass Differential Diagnosis Solid: • Benign: Hepatic Hemangioma, Focal nodular hyperplasia, Hepatocellular adenoma, Regenerative nodules •
Liver Mass Differential ... Diagnosis Solid ... disease, Biliary ... Cystadenocarcinoma, Primary ... #Diagnosis #hepatology
Liver Mass - Differential Diagnosis Algorithm Cystic: • Benign - Simple: Simple
Liver Mass - Differential ... Disease, Caroli's ... Malignant - primary ... - HCC, CCA, HB ... #Causes #Hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... disease 6-9 mo ... Calculate R-Value ... #Diagnosis #Management
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects, Drugs, Liver ... , Spiders - Enzyme ... #Diagnosis #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... cholestasis → Cirrhosis/Liver ... or higher • Liver ... bile ducts Differential ... #workup #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... Enzyme Elevation ... #diagnosis #algorithm ... #hepatology
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
The 6 C’s of Primary ... asymptomatic at diagnosis ... disease management ... #Primary #Sclerosing ... #Hepatology
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