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diagnosis neurology management infections syndromes treatment abg acid acidbase aids algorithm amyotrophic autoimmune base bloodgas compylobacterjejuni cranial disorders encephalitis flaccidpalsy
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Myasthenia Gravis ... life-threatening Differential ... Myotonic dystrophy - Brain ... Generalized fatigue - ALS ... Serologic and EMG
Multiple Cranial Neuropathies - High Yield Differential Diagnosis • Intrinsic brainstem process • Compressive brainstem process
Neurosarcoidosis • CNS ... important for facial weakness ... : • Myasthenia ... Gravis (much more ... #Diagnosis #causes
Causes of Hypotonic Infant (Floppy Newborn) - Differential Diagnosis Algorithm Central Nervous System - Decreased LOC, Axial
Causes of Hypotonic ... Normal Reflexes - Brain ... Hemorrhage • CNS ... and Transient Myasthenia ... Gravis •
Causes of Neuromuscular Weakness • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Weakness • Spinal ... Motor Nerves: ALS ... Eaton Syndrome, Myasthenia ... Gravis, Organophosphate ... #Causes #differential
Myasthenia Gravis - Summary • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... More likely to cause ... glucocorticoids - can cause ... #Gravis #diagnosis ... #management #neurology
Generalized Weakness - Differential Diagnosis Framework "l feel weak": • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis •
Resp/Heme: CHF, valves ... Polyneuropathy, ALS ... NMJ disorder (Myasthenia ... Diagnosis #causes ... #neurology
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... pulmonary etc) • CNS ... nervous system: Brain ... Postsynaptic: Myasthenia ... Gravis - Lack
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
PCR 50% sensitive ... lung nodules, may also ... RingEnhancing #Lesions #Brain ... #differential # ... diagnosis #causes
Guillain–Barré syndrome (GBS) (aka: Landry–Guillain–Barré–Strohl syndrome:  Most common cause of acute flaccid paralysis  Rapidly progressive ascending paralysis & areflexia  Autonomic
 Most common cause ... Differential diagnosis ... :  Myasthenia ... gravis: Intermittent ... Multiple Sclerosis: CNS
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
BEE Syndromes - ... affecting the brain ... nervous system (CNS ... Inflammatory causes ... #inflammatory #differential
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