12 results
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
Causes of Peripheral ... Sensory Changes - Differential ... Neuropathy • Spinal ... • Congenital Myopathy ... #Neurology #Differential
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
WeaknessSpinal ... Motor Nerves: ALS ... Eaton Syndrome, Myasthenia ... Mitochondrial myopathy ... #Causes #differential
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
Resp/Heme: CHF, valves ... I am weak": • Myopathy ... Polyneuropathy, ALS ... NMJ disorder (Myasthenia ... Diagnosis #causes
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
life-threatening Differential ... Generalized fatigue - ALS ... Serologic and EMG ... Gravis #diagnosis #management ... #neurology
Myasthenia Gravis - Summary
 • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
More likely to cause ... glucocorticoids - can cause ... Sinai Hospital of ... Gravis #diagnosis #management ... #neurology #treatment
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Weakness - Differential ... Lesions of the spinal ... Postsynaptic: Myasthenia ... Myopathy: ... #Differential #
Cauda Equina Syndrome Overview

Cauda Equina Syndrome:
 • Prevalence: 1:33,000-100,000 ppl/yr
 • Incidence: 1.5-3.4 million ppl/yr
 •
MCC- acute ... - Emergency Causes ... lower extremity weakness ... #diagnosis #causes ... #neurology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
rapid onset of weakness ... cord (Myelopathy ... Weakness: - Weakness ... Myelitis #diagnosis #management ... #neurology #differential
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Epidemiology: • 1-2 cases ... complete paralysis of all ... of intrathecal spinal ... Syndrome #diagnosis #management ... #treatment #neurology
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
brainstem and multiple spinal ... - Causes progressive ... EMG: LMN Signs in ... conditions listed in differential ... #diagnosis #management