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diagnosis lfts transaminitis algorithm arterial biliary chemistry cholangitis cholestatic cirrhosis classification embolism enzymes functiontest hematology hepatitis hepatocellular interpretation lactate lactic
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Injury ... • AST/ALT elevation ... • R value = (ALT ... + ULN ALT) / (alkaline ... #hepatology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
(LFTs) Elevation ... Transaminase >> Alkaline ... ≥ 2x ULN R Value ... Hepatocellular injury ... Transaminitis #diagnosis #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
(ALP) Elevation ... - Differential ... Intestine - Other causes ... #Elevation #Differential ... Diagnosis #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Algorithm Vascular Causes ... #differential # ... diagnosis #algorithm #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs R-value ... • Liver injury ... Enzyme Elevation ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... Labs: • Alkaline ... obstruction • ALP ... bile ducts Differential ... diagnosis #workup #hepatology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Acidosis - Differential ... to bolus these values ... or renal injury ... Injury: • Reduced ... #Elevation #Differential
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Syndrome, Ischemic Liver ... considered in all ... coagulation and other causes ... Vasculitis • Injury ... #differential #
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