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hepatology transaminitis causes lactate acidosis chemistry classification dehydrogenase drug druginduced elevated elevation function gastroenterology hepatocellular idiosyncratic induced interpretation laboratory lactic
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Differential Diagnosis ... Hepatopathy • Acute ... (>1000): • DILI ... injury) • Ischemic
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Injury (DILI) ... Chronic - ongoing ↑ LFTs ... Calculate R-Value ... #differential # ... gastroenterology #algorithm
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... #injury #hepatitis ... diagnosis #algorithm
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Diagnosis Hepatocellular ... #Injury #Differential ... #Diagnosis #Causes ... #Acute #algorithm
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Algorithm DILI ... dechallenge • Acute ... #Liver #Injury ... #Diagnosis #Algorithm
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... R-value: Serum ... #chemistry #diagnosis ... #differential # ... transaminitis #LFTs
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... > 20x normal - Acute ... #LFTs #transaminitis ... #differential # ... diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... : Liver Injury ... Injury Differential ... #Injury #Differential ... #LFTs #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Diagnosis Algorithm ... • Alcoholic hepatitis ... • Others #LFTs ... #Diagnosis #Algorithm
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Diagnosis Framework ... RBCs, muscle, liver ... - Prosthetic valves ... : • Early acute ... hepatitis • Acute
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