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hematology hemolytic algorithm classification extravascular intravascular management acidosis agglutinin antibody cold dehydrogenase disease elevated elevation gap globulin hepatitis hepatology hodgkins
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Hemolysis - Diagnostic ... • Increased LDH ... #Hemolytic #Anemia ... #Algorithm #Differential ... #Causes #Workup
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Hemolytic Anemia ... indirect bilirubin, ↑ LDH ... • Blood smear: Differential ... 2) LOOK FOR a cause ... #Hemolytic #Anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... - Differential ... Diagnosis Algorithm ... anemia • ... Prosthetic heart valves
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... anemia): ... - Drugs (Beta lactam ... #differential # ... #anemia
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... ) - Differential ... Diagnosis Framework ... - Prosthetic valves ... #diagnosis #Laboratory
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Membrane): - Autoimmune ... Defects: Sickle cell anemia ... Haptoglobin ↓ - Lactate
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
If the value is ... elevation Serum lactate ... dehydrogenase (LDH ... WBC count and differential ... #Workup #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... iron deficiency, hemolysis ... disorders (e.g. autoimmune ... Myelofibrosis (MF ... #Diagnosis #Causes
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral infection, autoimmune ... Diagnosis: • hemolytic ... Hyperbilirubinemia • Elevated lactate ... CLL (older) • Autoimmune ... younger pts) Differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... Diagnosis Algorithm ... Vascular Causes ... : Autoimmune hepatitis ... muscle, kidneys • LDH
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