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hematology algorithm causes elevation lactate acidosis classification dehydrogenase dm2 elevated erythematosus extravascular false folicacid hba1c hemolytic hgba1c increase intravascular lactic
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
Iron, B-12, or folate ... deficiency • ... blood loss • Hemolytic ... #Diagnosis #DM2 ... #Differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
- Differential ... Diagnosis Algorithm ... Cold AIHA • PCH ... anemia • ... Prosthetic heart valves
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... without platelet decrease ... #Anemia #Differential ... #workup #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... activity - A low value ... If the value is ... WBC count and differential ... #Workup #Hematology
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
Deficiency • Decreased ... pregnant have hemolytic ... anemia, or psoriasis ... #differential # ... diagnosis #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Drug-associated, PCH ... Defects: Sickle cell anemia ... Hypophostphatemia Laboratory
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
Dehydrogenase (LDH) - Differential ... Diagnosis Framework ... - Prosthetic valves ... Pneumocystis pneumonia (late ... #diagnosis #Laboratory
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... to bolus these values ... - assess other laboratory ... muscle use • Decreased ... 30mmHg) - Severe anemia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
and fever) and laboratory ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... disease • Prolidase deficiency ... lymphopenia, low PLT • Anemia
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