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hematology causes hemolysis oncology acidosis agglutinin algorithm chronic classification cold disease elevation extravascular gastroenterology hemolytic intravascular lactic mds myelodysplasia myelodysplastic
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Fragmentation - MAHA: TTP ... HELLP - Grafts, Valves ... Defects: Sickle cell ... anemia, Thalassemias ... Haptoglobin ↓ - Lactate
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... microangiopathies (TMA) - TTP ... organ or stem cell ... macroangiopathic hemolytic anemia ... Catastrophic APLS BCM IM
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Diagnosis Algorithm ... • Sickle cell ... immune-complex hemolytic anemia ... • MAHA (TTP ... Prosthetic heart valves
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... If the value is ... elevation Serum lactate ... WBC count and differential ... #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Hyperbilirubinemia • Elevated lactate ... malignancies - B-cell ... younger pts) Differential ... Disorders Such As ... sensitize red blood cells
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... e.g., uptake by cells ... www.ncbi.nlm.nih.gov/pmc ... to bolus these values ... 30mmHg) - Severe anemia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Thrombocytopenia (ITP ... Workup: • Complete ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis
Chronic Abdominal Pain Causes - Differential Diagnosis Framework Many patients with chronic abdominal pain have had prior
Pain Causes - Differential ... dysfunction • PSC ... malignancy • Lactase ... appendages • FMF ... Chronic #Causes #Differential
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... • No CRAB - no anemia ... lytic lesions • Lactate ... myeloma Diagnostic ... #Workup #Hematology
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