11 results
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Hemolysis - Diagnostic ... • Increased LDH ... #Hemolytic #Anemia ... #Causes #Workup ... #Hematology #Diagnosis
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
Differential diagnosis ... organ or stem cell ... anemia" • HELLP ... Catastrophic APLS BCM IM ... #diagnosis #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
Elevated Lactate ... ) - Differential ... Diagnosis Framework ... - Prosthetic valves ... #diagnosis #Laboratory
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Defects: Sickle cell ... anemia, Thalassemias ... Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential ... Diagnosis Algorithm ... • Sickle cell ... anemia • ... Prosthetic heart valves
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
If the value is ... elevation Serum lactate ... dehydrogenase (LDH ... WBC count and differential ... #Workup #Hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... Hyperbilirubinemia • Elevated lactate ... younger pts) Differential ... Disorders Such As ... #anemia #hematology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... e.g., uptake by cells ... www.ncbi.nlm.nih.gov/pmc ... to bolus these values ... 30mmHg) - Severe anemia
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... muscle, Kidneys • LDH ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... anemia • Pain ... classical HL (LDHL ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate