7 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Donath-Landsteiner Antibodies[PCH ... younger pts) Differential ... Hemoglobinuria (PCH ... #disease #hemolytic ... #anemia #hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
- Differential ... iron deficiency, hemolysis ... Myelofibrosis (MF ... #Differential # ... Diagnosis #Causes #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Approach to Thrombocytosis ... Platelet Count - Differential ... for workup, including ... blood loss, Acute hemolysis ... #Platelets #Differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential ... Cold AIHA • PCH ... Prosthetic heart valves ... Extravascular #Differential ... Algorithm #Causes #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential ... Agglutination - Cold agglutinins ... #Anemia #Differential ... Diagnosis #Algorithm #workup ... #hematology #testing
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... HELLP - Grafts, Valves ... Drug-associated, PCH ... #Differential # ... Diagnosis #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
activity - A low value ... If the value is ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology