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causes algorithm bruising activation bleeding hemolysis hemolytic intravascular macrophage management mas peds purpura
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... #diagnosis #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Diagnosis Algorithm ... Toxic Damage (e.g ... Displacement (e.g ... Diagnosis #Algorithm ... #Causes #Hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g ... #Causes #peds #pediatrics ... #diagnosis #differential
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Diagnosis Algorithm ... Thrombocytopenia ... Rare • Drugs (e.g ... #Diagnosis #Algorithm ... #Causes #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
the secondary or acquired ... underlying disease (eg ... • Infection (eg ... , and thrombocytopenia ... #Hematology #Rheumatology
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