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diagnosis differential causes rheumatology management algorithm arthritis classification lupus secondary sle acidosis activation bruising cardiology cerebritis cns crisis cryoglobulinemia cryoglobulins
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... underlying disease (eg ... lupus erythematosus ... • Infection (eg ... with leukopenia, anemia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: • Acute ... • Malignancy (e.g ... Endocrine disorders (e.g ... Pleural effusions • Acute ... lymphopenia, low PLT • Anemia
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Disorders secondary to Systemic ... Iron deficiency anemia ... halt nail growth (e.g ... • Nephrotic syndrome ... #Secondary #dermatology
Causes of Acute Pericarditis: Infectious; Viral: Adenovirus Coxsackie virus A and B Echovirus Epstein-Barr virus Hepatitis Human immunodeficiency
Cardiac injury (e.g ... Pericardial perforation (e.g ... pericarditis) Uremia ... Systemic lupus ... erythematosus
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 Inflammatory Joint Pain - Differential Diagnosis Algorithm Monoarticular • Gout (Podagra, Tophi) • Pseudogout • Early
• Reactive (e.g ... Enteropathic (e.g ... Lupus Erythematosus ... Sicca) Syndrome ... Enteropathic (e.g
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Lupus Erythematosus ... Demyelinating Syndrome ... Lumbar Puncture, EEG ... #Lupus #Erythematosus
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute ... malignancies • Anemia ... inflammatory disorders (e.g ... Myelodysplastic syndrome ... Diagnosis #Causes #hematology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... tissue disorder (e.g ... . systemic lupus ... erythematosus ( ... classification #rheumatology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
- SLE (systemic ... lupus erythematosus ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g
Differential Diagnosis of Acute Arthritis Crystal-induced arthritis: Calcium oxalate, gout, cholesterol, pseudogout, hydroxyapatite crystals Infectious arthritis: Bacteria, fungi,
Differential Diagnosis of Acute ... arthritis: Behçet syndrome ... lupus erythematosus ... spondyloarthropathy (e.g ... #Differential #Acute
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