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diagnosis differential rheumatology causes treatment algorithm systemic cardiology dermatology erythematosus infectiousdiseases lupus neurology renal sle acquired activation aspergillus autoimmune carcinoma
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Iron deficiency anemia ... halt nail growth (e.g ... • Bacterial endocarditis ... • Nephrotic syndrome ... Systemic #Secondary #dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... differential #diagnosis #hematology
Vascular Joint Pain - Differential Diagnosis Algorithm - Constant Pain (Ischemia) - Acute Onset -
• Sickle Cell Anemia ... Septic Embolism (e.g ... Fat Embolism (e.g ... Mycotic Aneurysm (e.g ... Marfan's Syndrome
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
tuberculosis, Abscess, Endocarditis ... Infected thrombosis, (e.g ... Lemierre's syndrome ... Malignancy: - Hematologic ... (e.g. autoimmune
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Neoplastic / Hematologic ... • Anemia • ... Infectious • Endocarditis ... • Drug Abuse (e.g ... Chronic Fatigue Syndrome
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Increased Requirement (e.g ... • Pancreatic Disease ... Myelodysplastic Syndromes ... • Liver Disease ... Algorithm #Causes #Hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... thrombocythemia), Autoimmune disease ... #treatment #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
nervous system (CNS ... (eg, systemic juvenile ... • Infection (eg ... with leukopenia, anemia ... #Hematology #Rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... Demyelinating Syndrome ... Cerebrovascular Disease ... Lumbar Puncture, EEG ... cerebritis #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... • Libman-Sacks endocarditis ... lymphopenia, low PLT • Anemia
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