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diagnosis differential causes rheumatology anemia treatment algorithm atlas clinical disorders microscopy neurology nomenclature rbc systemic acquired activation analysis basics bleeding
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... thrombocythemia), Autoimmune disease ... #treatment #hematology
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... hemolytic anemia (e.g ... cells: Sickle cell disease ... #Peripheral #Blood ... Smear #Analysis #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... differential #diagnosis #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Algorithm Normal Blood ... Increased Requirement (e.g ... Myelodysplastic Syndromes ... • Liver Disease ... Algorithm #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Chronic kidney disease ... infiltration (e.g ... Marrow suppression (e.g ... Intrinsic RBC defects (e.g ... Production #Index #hematology
Consensus Indications for Irradiated RBC Transfusions: Cellular blood components are irradiated for the prevention of TA-GVHD. Transfused
Transfusions: Cellular blood ... disorders (DiGeorge Syndrome ... HLA-selected products (e.g ... #Indications #Hematology ... #BloodBank #Management
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... anemia, Chronic disease ... Chemotherapy (e.g ... , McLeod blood group ... differential #diagnosis #hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
secondary to Systemic Diseases ... • Any systemic disease ... halt nail growth (e.g ... • Nephrotic syndrome ... Systemic #Secondary #dermatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... (eg, systemic juvenile ... • Infection (eg ... #Diagnosis #Management ... #Hematology #Rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
plateletcount), peripheral blood ... PT, aPTT(liver disease ... function test, ANA (e.g ... bypass), LFT (liver disease ... Causes #Workup #hematology
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