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diagnosis rheumatology lupus systemic dermatology erythematosus treatment activation algorithm blood bloodbank causes cerebritis classification cns coagulation comparison cryoglobulinemia cryoglobulins deficiencies
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malabsorption (e.g ... warfarin, DOACs (e.g ... Autoimmune disorders (e.g ... RA, SLE), Post-partum ... comparison #diagnosis #hematology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... 200ng/mL Best indications ... Special cases (e.g ... #rheumatology # ... levels #lupus #management
Consensus Indications for Irradiated RBC Transfusions: Cellular blood components are irradiated for the prevention of TA-GVHD. Transfused
Consensus Indications ... disorders (DiGeorge Syndrome ... HLA-selected products (e.g ... #Hematology #BloodBank ... #Management
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Abnormality • SLE ... halt nail growth (e.g ... Discoloration • Medications ... • Nephrotic syndrome ... Systemic #Secondary #dermatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... Lumbar Puncture, EEG ... Erythematosus #SLE ... cerebritis #diagnosis #management
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia Summary ... diseases: - 10% SLE ... tissue disorder (e.g ... erythematosus (SLE ... classification #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... activation and/or medications
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO Syndrome Summary ... antiinflammatory properties e.g ... #Rheumatology # ... diagnosis #management ... #Dermatology
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Muscle Toxicity - Summary ... Guillain-Barré syndrome ... erythematosus (SLE ... (SAMS-CI) • EMG ... myopathy #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... erythematosus [SLE ... • Infection (eg ... #Diagnosis #Management ... #Hematology #Rheumatology
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