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diagnosis rheumatology lupus pharmacology systemic dermatology erythematosus medications treatment algorithm antiil6 blood bloodbank causes cerebritis classification cns coagulation comparison covid19
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Malabsorption (e.g ... warfarin, DOACs (e.g ... Autoimmune disorders (e.g ... RA, SLE), Post-partum ... comparison #diagnosis #hematology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... 200ng/mL Best indications ... Special cases (e.g ... #rheumatology # ... levels #lupus #management
Vasopressors and Inotropes - Pharmacology Summary Vasopressors Phenylephrine (alpha-1) • Increases BP, SVR • Risk of reflex bradycardia
- Pharmacology Summary ... dependent receptor activation ... • D1 (1-2 mcg ... #Pharmacology #Summary ... #management #medications
Consensus Indications for Irradiated RBC Transfusions: Cellular blood components are irradiated for the prevention of TA-GVHD. Transfused
Consensus Indications ... disorders (DiGeorge Syndrome ... HLA-selected products (e.g ... #Hematology #BloodBank ... #Management
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Abnormality • SLE ... halt nail growth (e.g ... Discoloration • Medications ... • Nephrotic syndrome ... Systemic #Secondary #dermatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... Chronic B-cell activation ... and/or medications
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... underlying disease (eg ... erythematosus [SLE ... • Infection (eg ... #Management #Hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... Lumbar Puncture, EEG ... Erythematosus #SLE ... cerebritis #diagnosis #management
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19 IL-6 activates T cells and macrophages, among other cell types (see
other cell types (see ... “Cytokine Activation ... Syndrome” IL-6 ... #Pharmacology #Management ... #Medications
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia Summary ... diseases: - 10% SLE ... tissue disorder (e.g ... erythematosus (SLE ... classification #rheumatology
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