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diagnosis causes rheumatology algorithm activation acute anemia autoimmune bruising chronic classification conditions cryoglobulinemia cryoglobulins emergency erythematosus extrarticular extravascular fatigue fever
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Infected thrombosis, (e.g ... Lemierre's syndrome ... Malignancy: - Hematologic ... Inflammatory Diseases (e.g ... . autoimmune): Lupus
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
GI - Felty syndrome ... disease, Vasculitis (e.g ... , Marfan syndrome ... #joint #pain #differential ... #diagnosis #rheumatology
Inflammatory Joint Pain - Differential Diagnosis Algorithm Monoarticular • Gout (Podagra, Tophi) • Pseudogout • Early
• Reactive (e.g ... Enteropathic (e.g ... • Systemic Lupus ... Sicca) Syndrome ... Enteropathic (e.g
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... . lupus, CLL, lymphoma ... (usually IgM) (e.g ... deficiencies (e.g ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... • Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... vein thrombosis Hematologic
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
juvenile idiopathic arthritis ... disease • Systemic lupus ... underlying disease (eg ... SJIA], systemic lupus ... • Infection (eg
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue - Differential ... Neoplastic / Hematologic ... • Rheumatoid Arthritis ... • Drug Abuse (e.g ... Chronic Fatigue Syndrome
Causes of Acute Pericarditis: Infectious; Viral: Adenovirus Coxsackie virus A and B Echovirus Epstein-Barr virus Hepatitis Human immunodeficiency
Cardiac injury (e.g ... Pericardial perforation (e.g ... nodosa Rheumatoid arthritis ... Systemic lupus ... #Pericarditis #Differential
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 Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
arthralgia, and arthritis ... tissue disorder (e.g ... . systemic lupus ... SLE), rheumatoid arthritis ... classification #rheumatology
Differential Diagnosis of Acute Arthritis Crystal-induced arthritis: Calcium oxalate, gout, cholesterol, pseudogout, hydroxyapatite crystals Infectious arthritis: Bacteria, fungi,
Differential Diagnosis ... : Behçet syndrome ... sarcoid, systemic lupus ... spondyloarthropathy (e.g ... #Diagnosis #Differential
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