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diagnosis rheumatology erythematosus systemic treatment activation causes cerebritis classification cns cryoglobulinemia cryoglobulins differential hcq hydroxychloroquine levels macrophage mas measurement muscle
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... Lumbar Puncture, EEG ... Erythematosus #SLE ... cerebritis #diagnosis #management
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
(systemic lupus ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g ... #Causes #peds #pediatrics
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
manifestations: from easy bruising ... underlying disease (eg ... erythematosus [SLE ... • Infection (eg ... #Diagnosis #Management
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Measurement in SLE ... Special cases (e.g ... #rheumatology # ... pharmacology #levels #lupus ... #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... vein thrombosis Hematologic
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Guillain-Barré syndrome ... GBS), systemic lupus ... erythematosus (SLE ... (SAMS-CI) • EMG ... myopathy #diagnosis #management
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% SLE ... tissue disorder (e.g ... . systemic lupus ... erythematosus (SLE ... classification #rheumatology
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