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diagnosis rheumatology differential acquired activation algorithm causes cerebritis cns dermatology erythematosus hemeonc hemophagocytic hlh leukostasis lymphohistiocytosis lysis macrophage mas muscle
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Lumbar Puncture, EEG ... Treatment: ... cerebritis #diagnosis #management ... #treatment
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... • Infection (eg ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Diagnosis and Management ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... #treatment #hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
SLE (systemic lupus ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g ... #Causes #peds #pediatrics
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
any time during treatment ... GBS), systemic lupus ... (SAMS-CI) • EMG ... myopathy #diagnosis #management ... #treatment
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
organ damage • Treatment ... Low calcium • Treatment ... unless worrisome EKG ... TLS #diagnosis #management ... #hematology
Recurrent Polymorphic VT/Torsades de Pointes - Management Algorithm Drugs that prolong QT interval: • Class 1a (quinidine,
Torsades de Pointes - Management ... Congenital long QT Syndrome ... Hypocalcemia (rarely) Treatment ... 1 gm/hour • Pediatric ... /min • Pediatric
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
and lower jaw Treatment ... antiinflammatory properties e.g ... #Rheumatology # ... diagnosis #management ... #Dermatology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
▪ Infections (e.g ... pro-inflammatory cytokines (e.g ... Immunosuppression (e.g ... anti-IFN-γ antibodies (e.g ... #Hematology #HemeOnc
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