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diagnosis differential rheumatology causes algorithm erythematosus management sle vasculitis activation antibodies arthritis associations autoantibodies bruising cerebritis classification cns comparison cryoglobulinemia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... . lupus, CLL, lymphoma ... (usually IgM) (e.g ... deficiencies (e.g ... differential #diagnosis #hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Diseases Nail ... Iron deficiency anemia ... halt nail growth (e.g ... • Nephrotic syndrome ... #Secondary #dermatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Systemic lupus ... (eg, systemic juvenile ... • Infection (eg ... with leukopenia, anemia ... Diagnosis #Management #Hematology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
- Vasculitis, e.g ... - Vasculitis, e.g ... Microscopic polyangiitis ... #diagnosis #table ... #rheumatology #
Inflammatory Joint Pain - Differential Diagnosis Algorithm Monoarticular • Gout (Podagra, Tophi) • Pseudogout • Early
• Reactive (e.g ... Enteropathic (e.g ... Lupus Erythematosus ... Sicca) Syndrome ... Enteropathic (e.g
Small Vessel Vasculitides • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
manifestations (e.g ... Interstitial lung disease ... and C viruses. systemic ... lupus erythematosus ... and Sjogren's syndrome
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Demyelinating Syndrome ... Cerebrovascular Disease ... Lumbar Puncture, EEG ... CNS #neurology #rheumatology
Urine Microscopy Crystals Uric Acid crystals: - Formation promoted by acidic urine - Seen in tumor lysis
Urine Microscopy ... in tumor lysis syndrome ... disease Magnesium ... urease-producing organisms (e.g ... Crystals #comparison #table
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • Malignancy (e.g ... . hematologic) ... Endocrine disorders (e.g ... lymphopenia, low PLT • Anemia
Causes of Acute Pericarditis: Infectious; Viral: Adenovirus Coxsackie virus A and B Echovirus Epstein-Barr virus Hepatitis Human immunodeficiency
Tuberculosis Whipple disease ... Cardiac injury (e.g ... Pericardial perforation (e.g ... pericarditis) Uremia ... Systemic lupus
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