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diagnosis management differential erythematosus neurology symptoms vasculitis classification sle activation ana antinuclear autoantibodies autoimmune behcet cerebritis cryoglobulinemia cryoglobulins disease leukostasis
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... of Systemic Lupus ... Demyelinating Syndrome ... Lumbar Puncture, EEG ... #rheumatology #
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
(e.g. oculomotor ... AQP4-lgG disease; e.g ... pain • Extra-CNS ... lupus erythematosus ... neurology #symptoms #signs
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
(CNS) dysfunction ... underlying disease (eg ... • Infection (eg ... Diagnosis #Management #Hematology ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... • Malignancy (e.g ... Endocrine disorders (e.g ... and CNS • Headache ... #Diagnosis #Rheumatology
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
antibodies and Systemic ... SLE-SSc-AlM overlap syndromes ... p75 and there is no ... #diagnosis #rheumatology ... #table #ANA
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
pulmonary etc) • CNS ... -> PNS -> NMJ - ... central nervous system ... Lack of UMN/LMN signs ... electromyographic (EMG
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Systemic disease ... basal ganglia, CNS ... aneurysms Diagnosis: No ... diagnosis #management #signs ... #symptoms #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... Hyperviscosity Syndrome ... tissue disorder (e.g ... . systemic lupus ... classification #rheumatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... WBC >100k, + lab signs ... Hyperkalemia treatment (no ... unless worrisome EKG ... diagnosis #management #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Polyangiitis: - No ... inflammation Others: • Lupus ... lupus erythematosus ... purpura: strong sign ... differential #diagnosis #rheumatology
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