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diagnosis differential hematology erythematosus management systemic thrombocytopenia acidosis activation algorithm bruising cerebritis cns cryoglobulinemia cryoglobulins elevation extravascular hemolysis hemolytic intravascular
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Megakaryopoiesis • Aplastic Anemia ... Toxic Damage (e.g ... Displacement (e.g ... Autoimmune • ITP • SLE ... Foreign Surface (e.g
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... . lupus, CLL, lymphoma ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... Demyelinating Syndrome ... autoantibodies that will cause ... Lumbar Puncture, EEG ... CNS #neurology #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... • Malignancy (e.g ... Endocrine disorders (e.g ... lymphopenia, low PLT • Anemia
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... erythematosus [SLE ... • Infection (eg ... with leukopenia, anemia ... #Rheumatology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... (systemic lupus ... infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... tissue disorder (e.g ... . systemic lupus ... diagnosis #types #classification ... #rheumatology #
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
by excretion (e.g ... its metabolism (e.g ... - Compartment syndrome ... 30mmHg) - Severe anemia ... #typea #typeb #classification
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