39 results
Hyperviscosity Syndrome - Causes and Treatment

 - Waldenstrom macroglobulinemia (most common) / Plasmapheresis 
 - Multiple
- Causes and Treatment ... hyperleukocytosis (AML ... - MH/CCF/CWRU EM ... #Diagnosis #Treatment ... #Management
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Subacute-Acute: • Common: fever ... #APML #diagnosis ... #management #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... only curative treatment ... #Management #treatment ... #hematology #oncology
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
Fever vs Hyperthermia ... Neuroleptic malignant syndrome ... ; Serotonin syndrome ... Hyperthermia #comparison #diagnosis ... #management #treatment
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
Behcet's Syndrome ... refractory lesions • Derm ... Behcets #disease #Syndrome ... #Treatment #management ... #pharmacology #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... : Blast crises ... smear: Blasts APML ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Hantavirus
Pathogen: Hantavirus - Rodents are the primary reservoir
Transmission:
 • Shed in the urine, feces, saliva of
Cardiopulmonary Syndrome ... • Prodrome: fever ... +/- diarrhea Diagnosis ... • Autopsy PCR Treatment ... #management #treatment
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
high WBC count cause ... - 80% have fever ... organ damage • Treatment ... #TLS #diagnosis ... #management #hematology
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
Treatment depends ... Actively maintained fever ... #Differential #Causes ... Anesthesia #Checklist #Diagnosis ... #Management #Workup
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
disease • Periodic fever ... - Nonremitting fever ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology