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oncology differential hematology management conditions differentiation emergencies fungal hemeonc infectiousdiseases leukemia mycoses oncologic syndrome vasculitis
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
effusions, weight gain ... - pulmonary opacities ... : Infection (sepsis ... ), PE, DAH, CHF, ... #hematology #oncology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Bacterial or viral infection ... • Interstitial lung ... • Shrinking lung ... arteritis #Extrarticular ... #diagnosis #rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, fever, joint pain ... manifestations, hypoxia, CXR ... smear: Blasts APML ... #Leukemia #Hematology ... #Oncology #Diagnosis
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
symptoms • Rheumatologic ... muscle aches, joint ... pain, chest pain ... change in the lungs ... nails, bronchi, lungs
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... vesicular eruption • Joints ... Cerebrospinal fluid (CSF ... Palpable purpura, joint ... #Rheumatology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
if SSTI or port infection ... ; full infectious ... work-up - If febrile ... renal failure, pulmonary ... Oncology #HemeOnc #Diagnosis
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