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diagnosis hematology barre disease guillain hemophagocytic hlh lymphohistiocytosis neurology apml behcet capillary causes clarksons coagulation dic differential differentiation disseminated gbs
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
organ damage • Treatment ... Low calcium • Treatment ... - Hyperkalemia treatment ... TLS #diagnosis #management ... #hematology
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
like illnesses, COVID ... extremity, facial, respiratory ... patients) • Respiratory ... #diagnosis #management ... #treatment #neurology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... if WBC > 5 or elevated ... APML #diagnosis #management ... #hematology #oncology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... >500 ng/mL • Elevated ... • Bicytopenia Treatment ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
fibrinogen • Elevated ... dysfunction (19%) • Respiratory ... + Bleeding Treatment ... diagnosis #causes #treatment ... #management #hematology
Hyponatremia - Diagnosis and Treatment Hyponatremia is usually caused by the inability to excrete water normally.
2) Is ADH elevated ... Treatment: Treatment ... demyelination syndrome ... obtundation. coma. respiratory ... #management #nephrology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome ... Arthritis, AS Treatment ... inhibitors • Uveitis- Ophthalmology ... #diagnosis #management ... signs #symptoms #rheumatology
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... edema, compartment syndrome ... Hemoconcentration: elevated ... #diagnosis #management ... #rheumatology
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... extremity, facial, respiratory ... Puncture: - Elevated ... and cauda equina TREATMENT ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome ... Hyperferritinemia - Elevated ... Elevated soluble ... #Hematology #HemeOnc
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