10 results
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... organ damage • Treatment ... : • Pathophysiology ... Low calcium • Treatment ... diagnosis #management #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated ... Platelet Count - Differential ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... Thrombocytosis #Platelets #Differential
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Pathophysiology ... if WBC > 5 or elevated ... initiation • Differential ... diagnosis #management #hematology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
specificity to elevated ... rises later - Half ... • Gilbert's syndrome ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Etiology: • Pathophysiology ... Reversible course Differential ... CSF: Modestly elevated ... An elevated white ... epilepticus Treatment
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Liver Injury - Differential ... vein: Budd-chiari syndrome ... specificity to elevated ... rises later - Half-life ... • Gilbert's syndrome
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Behçet's Syndrome ... Behcet disease) Differential ... Arthritis, AS Treatment ... inhibitors • Uveitis- Ophthalmology ... signs #symptoms #rheumatology
Intermittent Bilateral Exophthalmos (Alternating Exophthalmos and Enophthalmos) on Physical Exam

Observing this patient in silence for a
Treatments are aimed ... The syndrome of ... Differentials for ... clinical #video #ophthalmology ... #physicalexam #
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome ... Hyperferritinemia - Elevated ... Pathophysiology ... Elevated soluble ... Diagnosis #Management #Hematology
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
TAFRO TAFRO syndrome ... cell lymphoma Pathophysiology ... Thrombocytopenia - Elevated ... Hypoalbuminemia Treatment ... diagnosis #management #rheumatology