2596 results
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... hyperviscosity syndrome ... organ damage • Treatment ... Low calcium • Treatment ... - Hyperkalemia treatment
Clarkson’s Disease - Capillary leak syndrome
Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... edema, compartment syndrome ... Hemoconcentration: elevated ... • No effective treatment ... Capillary #leak #syndrome
Management of Serotonin Syndrome
Identify and stop all serotoninergic medications
 • Avoid inadvertent Rx of serotoninergic meds
Management of Serotonin Syndrome ... agitation and mildly elevated ... ucsdim #Serotonin #Syndrome ... #Management #treatment
Fever vs Hyperthermia
Fever:
 • Regulated in the hypothalamic thermoregulatory center
 • "Set point" raised by prostaglandin
production • Treatment ... and decrease the elevated ... Neuroleptic malignant syndrome ... ; Serotonin syndrome ... • Treatment:
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... >500 ng/mL • Elevated ... soluble CD25 • Elevated ... • Bicytopenia Treatment ... diagnosis #management #treatment
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Encephalopathy Syndrome ... CSF: Modestly elevated ... An elevated white ... epilepticus Treatment ... underlying cause • Treatment
Hyponatremia - Diagnosis and Treatment
Hyponatremia is usually caused by the inability to excrete water normally.
Diagnosis and Treatment ... 2) Is ADH elevated ... Treatment: Treatment ... demyelination syndrome ... Differential #Diagnosis #Treatment
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... if WBC > 5 or elevated ... Renal Failure Treatment ... Differentiation #Syndrome
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
(Mannitol) • Elevated ... intraocular pressure • Elevated ... disequilibrium syndrome ... and nephrotic syndrome ... Tolvaptan) • Treatment