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differential rheumatology management signs algorithm systemic causes workup erythematosus dermatology oncology sle vasculitis hepatology secondary classification pancytopenia antinuclear arthritis autoantibodies
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
and Clinical Findings ... RA) or systemic lupus ... #Pathophysiology ... #Diagnosis #Signs ... #Symptoms
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... Autoimmune Hepatitis, Primary ... #diagnosis #differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... usually IgG) (e.g. lupus ... usually IgM) (e.g. primary ... , Copper and lead ... #hematology #anemia
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
- Primary angiitis ... - systemic lupus ... Vasculitis #Vessels #Diagnosis ... #Rheumatology # ... Diagnosis
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Inflammatory and ... : • Systemic lupus ... #Hematology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... Antinuclear (ANA ... Initial screening test ... #SLE #Summary #diagnosis ... #rheumatology #
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
15% of AIHA Primary ... Cold Agglutinin Syndrome ... Test: Donath-Landsteiner ... test #cold # ... #hematology #diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Hemolytic anemia ... Auto-Antibodies: - ANA ... and Lupus Mimickers ... autoantibodies #signs #symptoms ... #differential #rheumatology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Generalized Differential Diagnosis ... Algorithm - Systemic and ... Liver Function Tests ... renal failure/uremia ... Myelodisplastic syndrome
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... the context of primary ... lymphopenia, low PLT • Anemia ... : • Symptoms limited ... Erythematosus #Diagnosis
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