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hematology causes algorithm management anemia hemolytic syndrome workup aplastic chronic classification diffuse hodgkins lad lymphadenopathy lymphocytic lymphoma mds myelodysplastic pathophysiology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... pain, bleeding, infections ... bruising, bleeding, infection ... #Hematology #Oncology ... #Diagnosis
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Diagnosis Algorithm ... Pseudotumor - Infectious ... History of Bleeding, Infection ... #Causes #Hematology ... #Oncology
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Diagnosis Algorithm ... Inflammatory / Infectious ... • Neoplastic (Leukemia ... #Causes #Hematology ... #Oncology
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Neutrophils - Differential ... Diagnosis Algorithm ... Infection • ... • Metabolic disorders ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... weeks without infection ... lymphoproliferative disorders ... leukemia #CLL ... #oncology #hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... Diagnosis Framework ... Myeloproliferative Disorders ... Diabetes/DKA Infections ... : • helminth infections
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
e.g., HIV), EBV infection ... involved) • No leukemic ... Etiology: - Infections ... Diagnosis of B-Symptoms ... #oncology #diagnosis
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Due to Viral infection ... Polyclonal - Viral Infection ... Check For: • Infections ... Polyclonal IgM post infectious ... younger pts) Differential
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Diagnosis Algorithm ... Infectious • ... • Lymphoma • Leukemia ... Myeloproliferative disorders ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... Thrombocytosis): • Acute infection ... Chronic inflammatory disorders ... Chronic myeloid leukemia ... (CML) - Dr.
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