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differential causes management neurology syndrome gitelman heat heatstroke hypotonic illness oncology pathophysiology physiologic provoked rhabdomyolysis secondary sodium stroke table tls
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
8.0 mg/dL • Potassium ... Calcium ≤ 7.0 mg/dL Clinical ... TLS: • AKI (defined ... arrhythmia • Seizure ... Syndrome #TLS #diagnosis
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Causes of Hyponatremia ... Malignancy True hypovolemia ... • Reduced GFR, AKI ... #Nephrology #Differential ... #Diagnosis #Algorithm
Causes of Hyponatremia - Differential Diagnosis Algorithm Syndrome of Inappropriate ADH - Euvolemic; no physiologic stimulus to
Causes of Hyponatremia ... Malignancy True hypovolemia ... • Reduced GFR, AKI ... #Nephrology #Differential ... #Diagnosis #Algorithm
Causes of Secondary / Provoked Seizures - Differential Diagnosis Algorithm Febrile Infection • Sepsis • Encephalitis • Meningitis Metabolic
- Differential Diagnosis ... Algorithm Febrile ... Hyperglycemia • Hypocalcemia ... • Hyponatremia ... #Diagnosis #Algorithm
Causes of Seizures - Differential Diagnosis Algorithm Unprovoked - Epilepsy: • Focal: Simple, Complex • Generalized: Absence,
Causes of Seizures ... Algorithm Unprovoked ... Hyperglycemia, Hyponatremia ... Hypomagnesemia, Hypocalcemia ... #neurology
Physiologic Approach to Hypotonic Hyponatremia The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... Renal Losses (AKI ... Present (Uosm ≥100): Hypovolemia ... #differential #diagnosis ... table #sodium #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
exertion/training - Seizures ... Dermatomyositis Clinical ... Hyperuricemia • Hyponatremia ... Monitor potassium ... causes #treatment #nephrology
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
- Differential Diagnosis ... Loss of sodium/Potassium ... heat illness → Hypernatremia ... Rhabdomyolysis - AKI ... consciousness, Coma/seizure
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
tubule (DCT) Clinical ... (renal potassium ... tachycardia • Seizures ... Gitelman #Syndrome #diagnosis ... #nephrology #management
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