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diagnosis management differential classification disorders leukemia syndrome barre blood chronic guillain hemophagocytic hepatology hlh hodgkins lymphohistiocytosis lymphoma neurology apml cancer
Map of proliferative blood disorders. By Ariella Coler-Reilly @ariellastudies #Algorithm #classification #proliferative #blood #disorders #leukemia #hematology #oncology
ariellastudies #Algorithm ... disorders #leukemia #hematology ... #oncology #diagnosis ... #CML #CLL #AML
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... , CLL Acute leukemias ... ALL (Acute Lymphoblastic ... involvement CML ... ↓ LAP Score • CML
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Acute • Myloid ... (AML) - CD13, CD33 ... • Lymphoid (CLL ... CD23, o CML ... Blood #Disorders #hematology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
DNA (>10^6 IU/mL ... DNA (<2000 IU/mL ... DNA (>10^6 IU/mL ... DNA > 2000 IU/mL ... DNA > 2000 IU/mL
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Lymphomas • Other hematologic ... Malignancies (eg CML ... , ALL) • Solid ... NonHodgkins #comparison #oncology ... #differential #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
microglobulin Treatment ... Transform to DLBCL, PML ... ’s lymphoma or acute ... diagnosis #workup #oncology ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... • Induce blast cell ... Renal Failure Treatment ... diagnosis #management #hematology ... #oncology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
aspergillosis) - Viral (HIV ... Primary: - CML ... Mastocytosis - Acute ... Diagnosis #Causes #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... Responsive to Treatment ... Treated Like Acute ... relapse - Amy ... pathophysiology #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Ferritin >1000 ng/ml ... sIL-2R >2400 Ul/ml ... Unknown cause Treatment ... diagnosis #management #treatment ... #summary #rheumatology
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