17 results
Map of proliferative blood disorders. 

By Ariella Coler-Reilly @ariellastudies

#Algorithm #classification #proliferative #blood #disorders #leukemia #hematology #oncology
ariellastudies #Algorithm ... disorders #leukemia #hematology ... #oncology #diagnosis ... #CML #CLL #AML
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... , CLL Acute leukemias ... ALL (Acute Lymphoblastic ... involvement CML ... ↓ LAP Score • CML
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Differential Diagnosis Algorithm ... Acute • Myloid ... • Lymphoid (ALL ... CD23, o CML ... Blood #Disorders #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
microglobulin Treatment ... Transform to DLBCL, PML ... ’s lymphoma or acute ... diagnosis #workup #oncology ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... presents as an acute ... Low or absent NK cell ... Ferritin >500 ng/mL ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... Ferritin >1000 ng/ml ... sIL-2R >2400 Ul/ml ... Unknown cause Treatment ... #summary #rheumatology
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
DNA (>10^6 IU/mL ... DNA (<2000 IU/mL ... DNA (>10^6 IU/mL ... DNA > 2000 IU/mL ... DNA > 2000 IU/mL
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Triggers: ATRA treatment ... • Induce blast cell ... Renal Failure Treatment ... diagnosis #management #hematology ... #oncology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Differential Diagnosis Algorithm ... Responsive to Treatment ... Treated Like Acute ... relapse - Amy ... pathophysiology #Hematology
Algorithm regarding the diagnosis and treatment of Hereditary Hemochromatosis HH. 

Step 1: In the patient with
Algorithm regarding ... diagnosis and treatment ... Step 3: All patients ... SF of >1,000 μg/mL ... hemochromatosis #algorithm