18 results
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cause Organ Damage ... Labs/Diagnosis: ... DDX: • ANCA (Antineutrophil ... #diagnosis #types
Glomerulonephritis - Differential Diagnosis Framework
ANCA:
 • C-ANCA: GPA (Wegener's)
 • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
- Differential Diagnosis ... Framework ANCA: ... • ↓C4: Lupus, Cryoglobulinemia ... #differential #diagnosis ... #nephrology #causes
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Anti-dsDNA (in 70% of cases ... seen in 30—70% of cases ... • Sjögren syndrome ... Antinuclear #Antibody #ANCA ... Antineutrophil #antibodies #diagnosis
Causes of Purpura - Differential Diagnosis
Non-PalpabIe → Palpable
 • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Causes of Purpura ... - Differential Diagnosis ... complex mediated (cryoglobulins ... , IgA), ANCA associated ... #Differential #Diagnosis
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
pathophysiologic causes ... Lupus Nephritis, Cryoglobulinemia ... (C-ANCA): GPA > ... (P-ANCA): eGPA, ... #differential #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
- Differential Diagnosis ... tract, and often causes ... +MPO) • Cryoglobulinemic ... Low levels mixed cryoglobulinemia ... Serologies for Cryoglobulins
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... osmolarity If cause ... immunoglobulins, cryoglobulins ... #Differential #Diagnosis ... #nephrology #causes
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... Mnemonic C - Cryoglobulinemia ... autoimmune (RA, Sjogren's ... CHAMPS #Mnemonic #diagnosis
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
vasculitis, sepsis or cryoglobulinemia ... Cryofibrinogenemia Diagnosis ... • Negative causes ... Calciphylaxis • Cryoglobulinemia ... Cryofibrinogenemia #diagnosis
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... vasculitis/HSP • Cryoglobulinemia ... (MIXED) • ANCA ... Associated - SLE, Sjogren's ... #Differential #Diagnosis