17 results
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cause Organ Damage ... • Autoimmune diseases ... (e.g. systemic lupus ... classification #rheumatology
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear

Visual or auditory symptoms in conjunction
Inflammatory causes ... • Sjögren syndrome ... • Systemic lupus ... optica spectrum disorder ... #neurology #inflammatory
Mucous Membrane Disorder - Differential Diagnosis Algorithm
Erosions/Ulcers/Blisters
 - Primary Dermatologic Diseases
     •
Mucous Membrane Disorder ... Stevens-Johnson Syndrome ... • Systemic lupus ... MucousMembranes #dermatology ... Diagnosis #Algorithm #causes
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... Associated - SLE, Sjogren's ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... autoimmune (RA, Sjogren's ... S - Systemic Lupus ... #differential #hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... Erythematosus #SLE #CNS #neurology ... cerebritis #diagnosis #management
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Vasculitis - Collagen disorders ... Autoimmune Vasculitis (lupus ... , RA, Sjogren's, ... immunoglobulins & cryoglobulins ... #dermatology #physicalexam
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
involvement: Intractable nausea ... Comorbid autoimmune disorders ... (Systemic lupus ... erythematosus, Sjögren ... Manifestations #diagnosis #neurology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... usually IgG) (e.g. lupus ... lymphoproliferative disorders ... differential #diagnosis #hematology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Cryoglobulins ... cryoglobulinemia Associated Disorders ... • Negative causes ... Antiphospholipid syndrome ... #hematology