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diagnosis rheumatology ana lupus secondary sle algorithm mnemonic patterns treatment vasculitis workup anca antibody antineutrophil autoantibodies bcnie bloodculture cardiology cerebritis
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
BEE Syndromes - ... and less common diseases ... • Sjögren syndrome ... polychondritis • Behcet disease ... #Syndromes #neurology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... connective tissue disease ... (SLE), Sjogren's ... Syndrome (SS), ... #Antibodies #ANA
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Syndrome (SS), ... Syndrome, Myositis ... Lymphoproliferative Disorders ... rheumatology #diagnosis #differential
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
erythematosus ... • Sjögren syndrome ... connective tissue disease ... 90% • Anti-GBM disease ... #rheumatology #diseases
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... & renal involvement ... syndrome Anti-UI-ribonucleoprotein ... polymyositis overlap syndrome
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... antiphospholipid syndrome ... Lupus Erythematosus ... (total 50, renal
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... multisystemic disease ... SLE • Mikulicz syndrome ... Syndrome Diagnosis ... #Syndrome #Rheumatology
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
mainly AQP4-lgG disease ... Other brainstem syndromes ... mainly MOG-lgG disease ... (AQP4-lgG disease ... Sjögren syndrome
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Decade Skin Disease ... syndrome, and mixed ... lymphoma • Evans' syndrome ... lymphoproliferative syndrome ... Shrinking lung syndrome
MIAMI Mnemonic for Differential Diagnosis of Lymphadenopathy Malignancies - Kaposi sarcoma, leukemias, lymphomas, metastases, skin neoplasms Infections -
brucellosis, cat-scratch disease ... helminthic, Lyme disease ... syndrome, Still ... disease, systemic ... lupus erythematosus
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