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diagnosis rheumatology differential lupus sle ana anca antibody antineutrophil antinuclear bee cerebritis diseases inflammatory manifestations myelitis neuromyelitis nmo optica pericarditis
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
(CNS) involvement ... Inflammatory causes ... • Sjögren syndrome ... erythematosus ... optica spectrum disorder
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... #SLE #CNS #neurology ... cerebritis #diagnosis #management
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... ) • Systemic lupus ... erythematosus ... drug-induced SLE) • Systemic ... • Sjögren syndrome
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
pain • Extra-CNS ... Comorbid autoimmune disorders ... (Systemic lupus ... erythematosus, ... Sjögren syndrome
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... Hypocomplementemia • Can cause ... cirrhosis: 3%-20% Renal ... Distal (Type I) renal ... #Diagnosis #Management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... dermatomyositis, Sjogren ... and CNS • Headache ... APLA/LAC: • Renal ... 1, SCL-70, RNP antibodies
Causes of Acute Pericarditis: Infectious; Viral: Adenovirus Coxsackie virus A and B Echovirus Epstein-Barr virus Hepatitis Human immunodeficiency
Causes of Acute ... Procainamide Metabolic disorders ... : Renal Insufficiency ... syndrome Systemic ... lupus erythematosus
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 Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... - Sjogren - ... Antiamphiphysin antibodies ... Myelitis #diagnosis #management ... #neurology #differential
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
pulmonary and renal ... affects the skin, neurologic ... ischemia • Skin: Erythematous ... tract, and often causes ... chorioretinitis, CNS
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
, including systemic ... lupus erythematosus ... (SLE), Sjögren’ ... and the systemic ... TAFRO #diagnosis #management
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