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diagnosis differential treatment algorithm nephrology dermatology oncology systemic vasculitis classification erythematosus lupus sle anemia antibodies antinuclear bleeding blood bruising cryoglobulinemia
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... Associated - SLE, Sjogren's ... Differential #Diagnosis #hematology ... #rheumatology #
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
less common diseases ... Inflammatory causes ... • Sjögren syndrome ... optica spectrum disorder ... #neurology #inflammatory
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... autoimmune (RA, Sjogren's ... antiphospholipid syndrome ... #differential #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Sequestration Disordered ... ASA) • Renal Disease ... Connective Tissue Disorders ... #Hematology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Antinuclear (ANA ... & renal involvement ... heart block • Sjogren ... Summary #diagnosis #rheumatology ... #management
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
• Sjögren syndrome ... polyangiitis without renal ... + 30-60% • Renal-limited ... Jcortesizaguirr #ANA ... antibodies #diagnosis #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... PT, aPTT(liver disease ... function test, ANA ... (CVID, WAS), (neurologic ... #Workup #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Management • ... thrombocythemia), Autoimmune disease ... vonWillebrand #Syndrome ... #treatment #hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
erythematosus (SLE), Sjogren's ... Syndrome (SS), ... Syndrome, Myositis ... Lymphoproliferative Disorders ... #patterns #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Autoimmune diseases ... RA - 5 to 20% Sjögren's ... classification #rheumatology
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