8 results
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
Causes of Hypocomplementemia ... autoimmune (RA, Sjogren's ... #differential #hematology
Causes of Pericardial Effusion - Differential Diagnosis
Infectious:
 • Viral: Enterovirus, Herpesvirus, Adenovirus, Parvovirus
 • Bacterial: Mycobacterium
Causes of Pericardial ... Non-Infectious: • Rheumatologic ... Rheumatoid Arthritis, Sjogren ... Differential #Diagnosis #Causes
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
disorders, or other causes ... • Secondary Causes ... Associated - SLE, Sjogren's ... Differential #Diagnosis #hematology ... #rheumatology #
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Anti-dsDNA (in 70% of cases ... seen in 30—70% of cases ... • Sjögren syndrome ... antibodies #diagnosis #rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... RA - 5 to 20% Sjögren's ... rheumatoid arthritis, Sjögren's ... classification #rheumatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... enlargement Sjogren's ... Hypocomplementemia • Can cause ... or 3rd line #Sjogrens ... #Syndrome #Rheumatology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia 

DIAGNOSTIC CRITERIA FOR ICL
 • Persistent CD4 T-cell lymphopenia
 •
• Autoimmune (Sjogren ... ICL #diagnosis #hematology ... #Differential #Causes
Relapsing Polychondritis

What is it?
Recurrent inflammation of the cartilage in the body (Autoimmune disorder)

Who?
• Most frequently: 40
hearing loss, nausea ... diseases 30% of cases ... Most common • Sjogren ... Polychondritis #rheumatology