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diagnosis rheumatology hematology sle systemic signs activation agglutinin autoantibodies bee causes classification cold dermatologic disease gpa granulomatosis inflammatory macrophage management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematosus) ... erythematosus ( ... erythematosus ( ... • Erythematous ... erythematosus (
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... Inflammatory and ... Diseases: • Systemic lupus ... erythematosus
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... 69% - Malar rash ... anemia 4% - Myositis ... Diagnosis and Lupus ... #Erythematosus
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... , Vasculitis, Purpura ... ) Blood (75%): Anemia ... SLE #systemic #erythematosus ... #signs #symptoms
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
the brain, eye, and ... several common and ... early diagnosis and ... erythematosus ... vasculitides •
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
SLE (systemic lupus ... erythematosus) ... Meningococcal and ... infections - Vasculitis ... pediatrics #diagnosis #differential
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA) is common and ... Rarely dominate the clinical ... purpuric macules • Erythematous ... • Ulcerated, erythematous ... • Goodpasture syndrome
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitis and Vasculitides ... ischemia - Skin: erythematous ... mucositis - Rash ... erythematosus, ... Presentation - Systemic Symptoms
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
, such as IL-1 and ... hemophagocytosis and ... erythematosus ... • Heart, lung, and ... erythematosus [
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
pallor, dyspnea, and ... testing for anti-C3d and ... varicella, Citrobacter and ... hemoglobinemia and ... #anemia #hematology
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