9 results
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematosus) ... cutaneous lupus erythematosus ... (ACLE) • Erythematous ... cutaneous lupus erythematosus ... rashErythematous
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... , Vasculitis, Purpura ... ) Blood (75%): Anemia ... #systemic #erythematosus ... #signs #symptoms
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... 69% - Malar rash ... anemia 4% - Myositis ... Diagnosis and Lupus ... Systemic #Lupus #Erythematosus
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA) is common and ... Rarely dominate the clinical ... purpuric macules • Erythematous ... • Ulcerated, erythematous ... • Goodpasture syndrome
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
ischemia - Skin: erythematous ... mucositis - Rash ... systemic lupus erythematosus ... Presentation - Systemic Symptoms ... , and SLE) • Urinalysis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
pallor, dyspnea, and ... testing for anti-C3d and ... varicella, Citrobacter and ... hemoglobinemia and ... #anemia #hematology
Causes of Purpura or Easy Bruising in Children

Platelet count reduced, i.e. thrombocytopenia
 - Increased platelet destruction
thrombocytopenia) - SLE ... systemic lupus erythematosus ... Meningococcal and ... infections - Vasculitis ... pediatrics #diagnosis #differential
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... diseases, such as SLE ... ischemia • Skin: Erythematous ... , mucositis • Rash ... • Progressive symptoms
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
, such as IL-1 and ... hemophagocytosis and ... Systemic lupus erythematosus ... systemic lupus erythematosus ... [SLE], AOSD) •