46 results
Hemophagocytic Lymphohistiocytosis (HLH)
Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion
Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH) Clinical ... d-dimer, ↓ NK cell activity ... ): Molecular diagnosis ... fibrinogen • ↓ NK activity ... #hematology #criteria
Irritable Bowel Syndrome (IBS) - Diagnosis and Management Summary
Diagnosis:
 • Use a positive diagnostic strategy with
• Rome IV Criteria ... last 3 months + symptom ... • Global IBS Symptoms ... Rifaximin- up to 3 courses ... Secretagogues → activate
Clinical Manifestations of Serotonin Syndrome
 • Ophthalmologic: Mydriasis, Ocular clonus (slow horizontal movements)
 • Gastrointestinal: Diarrhea,
Clinical Manifestations ... sounds, RUQ pain • Dermatologic ... Hyperthermia UCSD ... Serotonin #Syndrome #Symptoms ... spectrum #signs #diagnosis
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
Risk factors: Critical ... without other cause ... ARDS to explain symptoms ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Osgood-Schlatter Disease - MSK Radiology
Imaging Findings:
 • Infrapatellar fat-pad edema with loss of the patellar tendon
: • Active adolescents ... exacerbated with activity ... tuberosity Differential diagnosis ... tear (similar symptoms ... #Radiology #diagnosis
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Definition: 
 • Severe adverse drug reaction, characterized by
Eosinophilia and Systemic Symptoms ... Symptoms: • The ... Edema in 70% of cases ... Criteria for Diagnosis ... DRESS #Syndrome #dermatology
Clinical manifestations of anaphylaxis. 
Neurological (<15%): Dizziness, syncope, seizures, Confusion, impending doom. headache
Angioedema: Lips, tongue, orbit,
Clinical manifestations ... arrest GI (>40%): Nausea ... anaphylaxis #signs #symptoms ... #diagnosis #criteria
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
Excessive glutamate activity ... - Causes progressive ... fasciculations Common Symptoms ... : months - Criteria ... : El Escorial criteria
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Tuberculosis - Diagnosis ... extrapulmonary cases ... Clinical Signs ... back pain - Symptoms ... of active pulmonary
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... increased B-cell activity ... renal failure Clinical ... are not caused ... at the time of diagnosis