46 results
Lactic Acidosis - Overview and Pathophysiology
Lactic acid is an endogenous substrate for gluconeogenesis, that is constantly
Lactic acid is an endogenous ... with exercise/activity ... why LR does not cause ... #differential #diagnosis ... #classification
The interferon (IFN) signature: what’s the point? How to use it in clinical practice?

Characterizing activity of
Characterizing activity ... pathway in the clinic ... understanding of pathophysiology ... To propose new classifications ... IFN #signature #diagnosis
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... Tuberculosis: • Endogenous ... characteristic features Clinical ... Tuberculosis Diagnosis ... Tuberculosis #TB #Diagnosis
Antiarrhythmics - Vaughan Williams Classification:
CLASS 1 - Sodium Channel Blockers:
 • MOA: Block fast Na+ channels
Vaughan Williams Classification ... node and AV node activity ... Vaughan #Williams #Pharmacology ... #Classification ... #Classes #pathophysiology
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... Tuberculosis: • Endogenous ... characteristic features Clinical ... Tuberculosis Diagnosis ... Tuberculosis #TB #Diagnosis
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia
If prolonged or ≥ 39 C this is a
39 C this is a clinical ... Treatment depends ... production • Actively ... maintained fever CAUSES ... Anesthesia #Checklist #Diagnosis
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
• Most common cause ... Lung Abscess Pathophysiology ... Lung Abscess - Clinical ... hemorrhage • Treatment ... #differential #causes
Antiarrhythmics Pharmacology Summary
Cardiac Conduction Phases:
Phase 0 - Ventricular Depolarization:
 • Na+ channels open leading to a
Antiarrhythmics Pharmacology ... Vaughan Williams Classification ... node and AV node activity ... #Classification ... #Classes #pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... accumulation of clinical ... Assessment • Clinical ... Treatment: • ... #management #treatment
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
Risk factors: Critical ... without other cause ... : 33% • Treatment ... : No • Treatment ... Reactions #hematology #diagnosis