13 results
Workup for Hyperphosphatemia - Differential Diagnosis Framework
Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
Phosphate Load: • Exogenous ... laxatives, Vitamin D toxicity ... Fosphenytoin • Endogenous ... Shift: • Lactic acidosis
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Colchicine Toxicity ... Naturally-occurring plant alkaloid ... • Metabolic acidosis ... #Colchicine #Toxicity
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... anion-gap metabolic acidosis ... Anion-Gap Metabolic Acidosis ... , Respiratory Alkalosis ... Salicylate #Aspirin #Toxicity
Lactic Acidosis - Overview and Pathophysiology
Lactic acid is an endogenous substrate for gluconeogenesis, that is constantly
Lactic Acidosis ... - Overview and Pathophysiology ... Lactic acid is an endogenous ... ) Lactic Acidosis ... differential #diagnosis #pathophysiology
Oxyhemoglobin Dissociation Curve 

Left Shift - decreased unloading of O2 at tissue level (i.e.  increased
- decr H+ (alkalosis ... - incr H+ (acidosis ... Dissociation #Curve #Pathophysiology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic Alkalosis ... /L • Gastric alkalosis ... chronic respiratory acidosis ... ectopic ACTH) • Exogenous ... #Metabolic #Alkalosis
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Associated Lactic Acidosis ... (MALA) Pathophysiology ... symptoms of metabolic acidosis ... LacticAcidosis #Toxicity
Intercalated cells response to Metabolic Alkalosis and Metabolic Acidosis
 • Type B Intercalated Cell - "B"
response to Metabolic Alkalosis ... and Metabolic Acidosis ... Intercalated #cells #pathophysiology
Salicylate Poisoning - Toxicology

Acute toxicity = vomiting, tachypnea, tinnitus, diaphoresis, and lethargy. This may progress to
Toxicology Acute toxicity ... mixed respiratory alkalosis ... and metabolic acidosis ... Chronic toxicity ... than with acute toxicity
Citrate Anticoagulation Toxicity

Hypernatremia (HyperNa):
 - Citrate solutions may have ↑ sodium content and should be paired
Anticoagulation Toxicity ... think citrate toxicity ... Anion-Gap Metabolic Acidosis ... metabolism Metabolic alkalosis ... Anticoagulation #Toxicity