Exogenous pathophysiology cdc clinical syndrome rheumatology hematology monoclonal disease

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Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,

for follow-up of monoclonal ... significance (MGUS) Mayo Clinic ... CBC, complete blood ... #monoclonal #gammopathy ... diagnosis #management #hematology

Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R

Multiple Myeloma and Monoclonal ... ULN R - Renal disease ... Cr >2 mg/dL or CC ... plasmacytoma, POEMs syndrome ... MGUS #diagnosis #hematology

Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
(+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia

of Clinical Significance ... capillary leak syndrome ... • Schnitzler syndrome ... Ig deposition disease ... Differential #Diagnosis #hematology

Cutaneous Manifestations of Monoclonal Gammopathy
• Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic

Manifestations of Monoclonal ... Cold agglutinin disease ... NaderYatim #monoclonal ... manifestations #dermatology ... #skin #clinical

Raynaud's Phenomenon on Physical Exam

#Raynauds #Syndrome #disease #phenomenon #clinical #video #physicalexam #fingers #hands #rheumatology

#Raynauds #Syndrome ... #disease #phenomenon ... #clinical #video ... fingers #hands #rheumatology

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Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

- Idiopathic monoclonal ... Cold Agglutinin Syndrome ... malignancy (CLL) - Monoclonal ... Viral Infection Clinical ... hemolytic #anemia #hematology

Raynaud's Syndrome - Washing off under hot water.
Raynaud phenomenon is an exaggerated vasoconstrictive response of the

Raynaud's Syndrome ... #Raynauds #Syndrome ... #disease #phenomenon ... #clinical #video ... fingers #hands #rheumatology

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VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
• Common Clinical Features: alveolitis, ear and

Clinical Syndrome ... : • Common Clinical ... thromboembolic disease ... criteria for 1) hematologic ... Autoinflammatory #Somatic #rheumatology

Raynaud's Syndrome - Washing off under hot water wath.

Raynaud phenomenon is an exaggerated vasoconstrictive response of

Raynaud's Syndrome ... #Raynauds #Syndrome ... #disease #phenomenon ... #clinical #video ... fingers #hands #rheumatology

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Diagnosis of Cryoglobulinemia Vasculitis

1) Presence of cryoglobulin
Circulating immunoglobulins that precipitate with cold temperature and dissolve

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