39 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... typically prolong aPTT ... may prolong the aPTT ... Prolonged PT and aPTT ... intravascular coagulation (DIC
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... , FVII, FIX, FX) ... intravascularcoagulation (DIC ... #Abnormal #PT #aPTT
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Thromboplastin Time (PTT ... warfarin) • Factor VII ... Thromboplastin Time (PTT ... elevated in: • DIC ... thematttsai #PT #PTT
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation (DIC ... • Prolonged PT/PTT ... levels of factors VII ... PT/INR: ↑ • PTT ... INR < 2.3 - APTT
Thrombotic Thrombocytopenic Purpura (TTP) vs Disseminated Intravascular Coagulation (DIC)
#Diagnosis #TTP #DIC #Comparison #Table #Laboratory #Findings #RebelEM
Intravascular Coagulation (DIC ... Diagnosis #TTP #DIC ... #Comparison #Table
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
NORMAL PT/NORMAL PTT ... evaluation of factor VII ... Inherited: • Factor VII ... Warfarin • Acute DIC ... disease • Acute DIC
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Intravascular Coagulation (DIC ... aggregation PT, aPTT ... small vessels #DIC
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
thromboplastin time (PTT ... decompensated DIC ... Diagnosis #Honc #DIC
Causes of AKI in Pregnancy - Differential Diagnosis
Creatinine - Platelets - Transaminases - LDH - PT/PTT
Transaminases - LDH - PT/PTT ... Diagnosis #Causes #table
Disc Herniations - Pathogenesis and Complications
• 90% of Lumbar disc herniations happen at L4/5 and L5/S1
•
Disc Herniations ... 90% of Lumbar disc ... 60% of cervical disc ... the vertebral disc ... -> Disc less able