69 results
Hemostasis Physiology

The blood's response to blood vessel injury can be viewed as four interrelated steps. 
Roman
to coagulation factors ... PF-3, platelet factor ... #Hemostasis #Pathophysiology ... #Coagulation #Cascade ... #Hematology
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Coagulation Cascade ... AntiCoagulation #Cascade ... #Pharmacology #Pathophysiology ... Mechanisms #DOAC #Hematology
Coagulation Cascade Mnemonic - PITT vs PET
PITT (with an I) = Intrinsic = APTT
Coagulation Cascade ... Extrinsic=PT Factors ... Common Pathway: Factors ... #Coagulation #Cascade ... PET #diagnosis #hematology
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
the Coagulation Cascade ... Initiation phase caused ... #Coagulation #Cascade ... diagnosis #models #hematology ... #pathophysiology
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Biliary Cirrhosis - Pathophysiology ... Environmental Risk Factors ... Epigentics Risk Factors ... Genetic Risk Factors ... mediated autoimmune cascade
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Causes include : ... Pre-analytical cause ... Decreased factor ... aPTT #Prolonged #Causes ... #differential #hematology
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
either a clotting factor ... inhibitor of normal factor ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation cascade ... generated by Tissue Factor ... #Coagulation #Cascade ... diagnosis #models #hematology ... #pathophysiology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... Decreased factor ... aPTT #Prolonged #Causes ... #differential #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Acquired Risk Factors ... Thrombophilia: - Factor ... coagulation and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential