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diagnosis hematology anticoagulation management comparison differential hemostasis pharmacology treatment anticoagulant anticoagulants apixaban arterial bleeding bruising cardiology cardiomyopathy causes clot dabigatran
Review of the Coagulation Cascade Traditional Model: • Parallel extrinsic and intrinsic pathways. Contemporary Model: • 4 key
Review of the Coagulation ... Cascade Traditional ... common pathway): Thrombin ... #Cascade #diagnosis ... #pathophysiology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... generated by Tissue Factor ... #Coagulation #Cascade ... PTT #diagnosis #models ... #hematology #pathophysiology
Hemostasis Physiology The blood's response to blood vessel injury can be viewed as four interrelated steps. Roman
numerals refer to coagulation ... factors. ... PF-3, platelet factor ... #Hemostasis #Pathophysiology ... #Coagulation #Cascade
Coagulation Cascade - Actions of Anticoagulants • Heparin: Unfractionated heparin, Enoxaparin, Daltaparin • Fondaparinux • Direct
Coagulation Cascade ... Fondaparinux • Direct Factor ... Warfarin • Direct Thrombin ... EricsMedicalLectures/ #Coagulation ... #Cascade #Anticoagulants
Summary table of the mechanism of action, side effect and contraindications of commonly used anti-coagulation drugs.
Summary table of ... commonly used anti-coagulation ... rivaroxaban - Direct thrombin ... (factor lla) inhibitors ... doac #comparison #table
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Summary of Coagulation ... Deficiency of Factor ... inhibitors, direct thrombin ... EricsMedicalLectures/ #Coagulation ... Deficiencies #Summary #table
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Consumption of Clotting Factors ... • Increased thrombin ... Reduced levels of factors ... protein C and S Pathophysiology ... Exposure → Tissue factor
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Acquired Risk Factors ... Thrombophilia: - Factor ... cardiovascular risk factors ... intravascular coagulation ... Venous #Arterial #pathophysiology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... factor == NORMAL ... integrity Clotting cascade ... intravascular coagulation ... warfarin, direct thrombin
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
of angiogenic factors ... Risk Factors and ... LVEDd > 6.0 cm, LV thrombus ... Planning for delivery mode ... during Delivery • Stable
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