12 results
Neuromyelitis Optica (NMO) - Clinical Manifestations
 • Optic neuritis: Reduced visual acuity, ranging from mild to
• Transverse myelitis ... Sjögren syndrome, Myasthenia ... gravis, Many others ... Manifestations #diagnosis #neurology ... #symptoms #signs
Myasthenia Gravis Overview

Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction.  Ab to
Myasthenia Gravis ... test - Cogan sign ... - Peek sign ... immunologic assay - MuSK ... #management #neurology
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Demyelinating Disease (MS ... Tetanus, Transverse Myelitis ... Eaton Syndrome, Myasthenia ... Gravis, Organophosphate ... differential #diagnosis #neurology
Ocular Myasthenia Gravis on Physical Exam

A 41yo female was referred by her neurologist for double vision.
Ocular Myasthenia ... Myasthenia gravis ... such as cogan sign ... tumor, and always ask ... ophthalmology #neurology
Myasthenia Gravis - Summary
 • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis ... likely to cause ... glucocorticoids - can cause ... #Gravis #diagnosis ... #management #neurology
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Proximal Weakness, Normal ... CK - Myositis ... Myopathy (Also caused ... Erythematosus #SLE #MSK ... pathophysiology #signs
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Postsynaptic: Myasthenia ... Gravis - Lack ... of UMN/LMN signs ... aminotransferases • Serology ... Differential #Diagnosis #neurology
Hoffman's sign. Even in this specific case, accompanied by a clonus outline (rhythmic contractions). The median
Hoffman's sign. ... this specific case ... #Hoffmanns #Sign ... Reflex #Positive #Abnormal ... clinical #video #neurology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
10-33% develop MS ... • Bilateral signs ... Sjogren's • CSF: - Abnormal ... • Infectious causes ... diagnosis #management #neurology
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
• Symptoms and signs ... injury • Gait is abnormal ... Non-compressive Spinal Cord Causes ... - Transverse myelitis ... disorders #diagnosis #neurology